quality of life after total thyroidectomy

a Postop: postoperative. official website and that any information you provide is encrypted Current evidence shows that psychological-related HrQoL is likely impaired in TT patients compared with the general population. Lan Y., Cao L., Song Q., Jin Z., Xiao J., Yan L., Luo Y., Zhang M. The quality of life in papillary thyroid microcarcinoma patients undergoing lobectomy or total thyroidectomy: A cross-sectional study. Global PSQI scores range from 0 to 21, where lower scores denote better sleep quality [47]. Finally, nine studies directly compared physical-related HrQoL for patients undergoing TT versus HT using six different questionnaires (EORTC-QLQ-C30, EORTC-QLQ-THY34, SF-36, THYCA-QoL, FoP-Q-SF, and KT-QoL) [52,56,57,59,60,62,64,65,67]. It is a general questionnaire comprised of 36 items measuring eight different scales [25,26]. There is a congruity between the research methodology and the research question or objectives? Q5. Measurement and variation in estimation of quality of life effects of patients undergoing treatment for papillary thyroid carcinoma. It is very important that the parathyroid glands be carefully peeled away from the thyroid and left in the neck by the surgeon during thyroid surgery. References identified by hand-search, expert recommendations, or through reference lists of included studies were also considered. All authors have made substantial contributions to this manuscript, approved the submitted version, and agree to be personally accountable for the integrity of this work. Diamond-Rossi S.A., Jonklaas J., Jensen R.E., Kuo C., Stearns S., Esposito G., Davidson B.J., Luta G., Bloom G., Graves K.D. Of 2507 identified records, 25 fulfilled the inclusion criteria. Of the cancer cohort, 95% had differentiated thyroid cancer and 83% remained disease-free. Careers, Unable to load your collection due to an error. The Korean Thyroid QoL questionnaire (KT-QOL) is the validated Korean translation of the QOL-Thyroid Scale, first developed by Dow et al. Extent of surgery for papillary thyroid cancer is not associated with survival: An analysis of 61,775 patients. Quality assessment of cross-sectional studies. Similarly, the total symptom burden score improved from 56.88 before surgery to 39.6 in the short term after surgery (P < .001), but there was not a significant improvement long term. Low levels of PTH cause hypocalcemia, or too little calcium in the blood. What is the experience of our patients with transient hypoparathyroidism after total thyroidectomy? The 15D instrument is a general HrQoL questionnaire assessing 15 different dimensions that can be used both as a profile and as a single index instrument [34]. Four references were identified by hand-searched expert recommendations. Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: An analysis of the PROFILES Registry data. Social functioning and integration may then in turn directly affect psychological and physical health. Studies including patients with medullary or anaplastic thyroid cancer were excluded. Q5. This is important information, since a person diagnosed with thyroid cancer should know the possible side effects of thyroid surgery, and be able to discuss these side effects, when choosing a thyroid surgeon. Mendelsohn A.H., Elashoff D.A., Abemayor E., St John M.A. Billewicz W.Z., Chapman R.S., Crooks J., Day M.E., Gossage J., Wayne E., Young J.A. Q4. Eight studies compared postoperative TT HrQoL with community reference values using seven different QoL instruments (i.e., SF-36, MFI-20, ThyPRO, PSQI, Billewicz Score, visual analog scale, and 15D) [18,34,51,53,55,58,61,68]. No studies compared HT patients HrQoL with community reference values. Epub 2020 Dec 1. Comparison between patient-perceived voice changes and quantitative voice measures in the first postoperative year after thyroidectomy: A secondary analysis of a randomized clinical trial. Rajjoub S.R., Yan H., Calcatera N.A., Kuchta K., Wang C.E., Lutfi W., Moo-Young T.A., Winchester D.J., Prinz R.A. Thyroid lobectomy is not sufficient for T2 papillary thyroid cancers. Among these, two found a decreased global HrQoL compared with community reference values [18,58]. Fourth, the scope of our review did not allow us to assess the impact of thyroid surgery on the HrQoL of patients who are ultimately found to have benign diseases. This is the first study to examine patient-reported outcomes in Graves disease patients undergoing thyroidectomy in North America and the first to analyze patient characteristics associated with patient-reported outcomes before and after thyroid surgery, Hadiza S. Kazaure, MD, an endocrine surgery fellow at Duke University School of Medicine, and colleagues wrote. . Parathyroid hormone (PTH): the hormone that regulates the bodys calcium levels. This study aimed to assess the QoL in patients with chronic HypoPT independently from their concurrent hypothyroidism and other comorbidities. Our findings highlight the multidimensional nature of HrQoL and the importance of a multitude of factors aside from treatment choice and related morbidities, such as the experience of receiving a cancer diagnosis, the fear of cancer recurrence, and other psychosocial factors. Q2. Quality-of-life outcomes in Graves disease patients after total Q4. The best way to minimize this risk is to choose a surgeon who specializes in thyroid surgery and thus has lots of experience in recognizing and preserving the parathyroid glands during surgery. More studies have compared postoperative TT social-related HrQoL with community reference values and indicate that social wellbeing may be decreased in this patient population compared with the general population. Qualitative Studies in Quality of Life: Methodology and Practice. SF-36 total score as a single measure of health-related quality of life: Scoping review. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. When this is done by a surgeon who specializes in this kind of surgery, thyroid surgery is safe and effective. Fear of cancer recurrence, anxiety and depressive symptoms in adolescent and young adult cancer patients. 1Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada; ac.lligcm@yrdnal.ennaiviv, 2School of Communication Sciences and Disorders, McGill University, Montreal, QC H3A 0G4, Canada, 3Faculty of Medicine, McGill University, Montreal, QC H3A 0G4, Canada; ac.lligcm@inailicis.htebazile, 4Gerald Bronfman Department of Oncology, McGill University, Montreal, QC H3A 0G4, Canada; ac.lligcm@yrneh.assilem, 5Department of Otolaryngology-Head and Neck Surgery, McGill University Health Center, Montreal, QC H4A 3J1, Canada, 6Lady-Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada, 7Segal Cancer Centre, Jewish General Hospital, Montreal, QC H3T 1E2, Canada, 8Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, Montreal, QC H3T 1E2, Canada. Strings Attached: CADTH Database Search Filters. One study found decreased general health in TT patients [59] The remaining two studies observed transitory impairments in global HrQoL in TT patients compared to HT patients, which subsided with time (6 months and 1 year postoperatively, respectively) [67]. Seven studies directly compared HT and TT patients in terms of global HrQoL [52,56,57,59,62,65,67]. The EORTC module for quality of life in patients with thyroid cancer: Phase III. This standard of care achieved an excellent prognosis: 5-year relative survival of 98.3% and recurrence rates of 3% in low-risk differentiated thyroid carcinoma (DTC), which accounts for the vast majority of new thyroid cancer diagnoses [5,6,7]. Scores range from 0 to 120, with higher scores denoting a greater handicap [50]. Several limitations limit the conclusions that can be drawn from included studies. Patient-reported outcomes were measured with the MD Anderson Symptom Inventory. One study found a significant increase in cognitive problems following TT, which were stable from two years following surgery up to four years following surgery [68]. First, the important heterogeneity of included studies, both in terms of QoL instruments used, and postoperative times of assessment limited comparison across studies and did not allow for a meta-analysis to be performed. Lori Wirth, MD, provides an overview of differentiated thyroid cancer including treatment options that are currently available, as well as sharing insights on emerging therapies. Due to limited resources for the translation of studies, only articles written in English or French were included. Appropriate statistical analysis was used? Appropriate statistical analysis was used? This study documents that patients who can get away with hemithyroidectomy when appropriately selected are going to be happier long-term than people with total thyroidectomy, said Christopher Umbricht, MD, PhD, an associate professor of oncology at Johns Hopkins Sidney Kimmel Cancer Center, in an interview with Cancer Network. Current research is nuanced concerning a potential decrease in global HrQoL in TT patients compared with the general population. Thyroid surgery is usually safe but adverse events can occur. For the purposes of this review, any surgical intervention restricted to one lobe of the thyroid, with or without isthmusectomy, was classified as a HT (lobectomy). Introduction. Anxiety and fear of recurrence despite a good prognosis: An interview study with differentiated thyroid cancer patients. Lastly, the inherently subjective and culturally sensitive nature of HrQoL assessed through patient-reported questionnaires could have contributed to the high heterogeneity of results across included studies. Exposure was measured in a valid and reliable way? Q2. Yang S., Xu X. Anxiety and quality of life among papillary thyroid cancer patients awaiting final pathology results after surgery. One study observed significantly more anxiety, depression, emotional functioning impairment, and psychological symptoms at one month postoperatively in TT patients versus HT patients [65]. Table of Contents | PDF File for Saving and Printing, THYROID CANCER In this review, 16 studies reporting on social functioning through 10 different instruments (SF-12, SF-36, MFI-20, ThyPRO, FoP-Q-SF, FoP, EORTC QLQ-C30, EORTC QLQ-THY34, KT-QoL, 15D) were identified [18,34,51,52,53,54,55,56,57,58,59,61,62,65,67,68]. Four studies found a significant decrease in psychological-related HrQoL for the following items: psychological symptoms (n = 1), emotional functioning (n = 1), state anxiety (n = 1), and mental health (n = 1) for patients undergoing TT versus HT [56,59,62,63]. Directly related to the physical and psychological components of HrQoL is the social functioning component; that is, the ability to fulfill social roles and maintain social relationships, interactions, and societal integration [84]. ; visualization: V.L., E.S., M.H. Giesinger J.M., Kuijpers W., Young T., Tomaszewski K.A., Friend E., Zabernigg A., Holzner B., Aaronson N.K. Nineteen studies were cross-sectional in nature, while six studies were transversal. For the two studies comparing postoperative TT HrQoL with AS, significant impairments were found in the surgery group for global physical subscale (n = 1), weight gain (n = 1), problems with scar (n = 1), and vocal symptoms (n = 1) [60,67]. The Fear of Progression questionnaire (FoP) is a 43-item instrument used to assess anxiety and fear related to disease progression [36]. Perros P., Boelaert K., Colley S., Evans C., Evans R.M., Gerrard Ba G., Gilbert J., Harrison B., Johnson S.J., Giles T.E., et al. Parathyroid glands: usually four small glands located around the thyroid that secrete parathyroid hormone (PTH) which regulates the bodys calcium levels. Patients who received a total thyroidectomy (without neck dissection) were 1.5 times more prone to report an HRQOL issue or an adverse effect of treatment vs patients who received a hemithyroidectomy (odds ratio, 1.49; 95% CI, 1.042.12). Three studies reported no significant difference between the DTC TT group and the general population or patients having undergone TT for benign disease [51,55,68]. Dionisi-Vici M., Fantoni M., Botto R., Nervo A., Felicetti F., Rossetto R., Gallo M., Arvat E., Torta R., Leombruni P. Distress, anxiety, depression and unmet needs in thyroid cancer survivors: A longitudinal study. There is a statement locating the researcher culturally or theoretically? 2012. Thyroidectomy - Mayo Clinic HUI2 scores range from 0.03 to 1.0, while HUI3 scores range from 0.36 to 1.0 [33]. In this interview we discuss a study that found that survivors of thyroid cancer diagnosed with the disease at a young age had an increased risk of late effects from therapy. No studies compared preoperative and postoperative HrQoL for HT patients. (2020) [27], Nies et al. One study found a transitory impairment in physical function, fatigue, pain, neuromuscular symptoms, vocal symptoms, libido, feeling chilly, or tingling symptoms in TT patients compared with HT patients between one and three months following surgery, although this difference was no longer significant at six months postoperatively. 1. Impact of total thyroidectomy on quality of life at 6 months: the - eje c PTC: papillary thyroid carcinoma. Among the 89 thyroid cancer patients who had thyroid surgery at one of these centers during the study, 17 had permanently low parathyroid hormone levels after surgery and 72 had normal post-surgery parathyroid hormone levels. And if youre comparing with hemithyroidectomy, intuitively youre doubling the risk that the surgery is going to damage some of the very sensitive anatomy around the neck. Nonempirical studies were excluded (i.e., reviews, comments, letters, editorials, interviews). As anxiety is clearly related to follow-up routines, these should therefore be reevaluated. A system review and meta-analysis found that the use of radiofrequency ablation for low-risk metastatic papillary microcarcinomas of the thyroid was safe and effective. Researchers conducted a content analysis of survey responses from 1,005 patients with DTC. Haugen B.R., Alexander E.K., Bible K.C., Doherty G.M., Mandel S.J., Nikiforov Y.E., Pacini F., Randolph G.W., Sawka A.M., Schlumberger M., et al. Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. Differences in long-term quality of life between hemithyroidectomy and total thyroidectomy in patients treated for low-risk differentiated thyroid carcinoma. The results of this questionnaire were then compared between patients having permanently low parathyroid hormone levels after surgery and patients with normal post-surgery parathyroid levels. Doubleday A.R., Robbins S.E., Macdonald C.L., Elfenbein D.M., Connor N.P., Sippel R.S. Each subscale is scored from 4 to 20 and converted to a global fatigue score ranging from 20 to 100, with higher scores indicating more impairment [46]. The Pittsburgh Sleep Quality Index (PSQI) is a 19-item instrument evaluating seven different components of sleep [47]. There were no significant differences in overall HRQoL scores between groups. Anxiety is a commonalthough partially hiddenproblem in DTC survivors, as they tended to deny it early in the dialogues. compared patients having undergone TT for DTC versus benign disease and reported a greater impairment in the sexual life of DTC patients [51]. This finding is consistent withand may also be explained bythe greater impairment in physical-related HrQoL that was observed in TT patients compared with HT patients. Patient-reported symptoms, including quality of life and thyroid-specific symptoms, of Graves patients improved significantly from their baseline prior to surgery both shortly after and longer after the surgery, the researchers wrote. These symptoms were often reported in association with regrets or dissatisfaction with treatment or the healthcare system in general [69,72]. The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/curroncol29070350/s1, Table S1: Search Strategy. Postoperative Chronic Hypoparathyroidism and Quality of Life After Scores range from 0 to 100, with high scores denoting more impairment [44]. The THYCA-QoL is a 24-item questionnaire that was designed specifically to assess HrQoL in thyroid cancer survivors. A visual analog scale (VAS) was used by Teliti et al. There is a congruity between the research methodology and the methods used to collect data? Second, the vast majority of included articles were cross-sectional, which limits the establishment of causal relationships. Two studies compared the social-related HrQoL of patients undergoing surgery versus AS and found a significant decrease in the social subscale (n = 4), social functioning (n = 1), and role limitations due to physical or emotional health (n = 1) [54,67]. Qualitative research furthermore emphasizes therapeutic alliances and relationships with healthcare providers as decisive factors in DTC patients HrQoL. Q7. Dingle I.F., Mishoe A.E., Nguyen S.A., Overton L.J., Gillespie M.B. BACKGROUND PMID: 32918085. d FTC: follicular thyroid carcinoma. Current research highlights that, whether patients undergo TT or HT, the decision of undergoing thyroid surgery has far-reaching consequences that can affect long-term HrQoL. The influence of the researcher on the research, and vice-versa, is addressed? Scores are derived into an EQ-5D index value. The initial search resulted in a total of 2507 records that were imported into the Covidence systematic review software Version v2625 (Veritas Health Innovation, Melbourne, Australia) for screening and eligibility assessment (Figure 1). Q8. Home Patients Portal Clinical Thyroidology for the Public February 2021 Vol 14 Issue 2 p.9-10, Summaries for the Public from recent articles in Clinical Thyroidology Adequate physical and psychological statuses indeed allow for healthy social functioning, which thus perhaps represents a more outcome-based component of HrQoL. Items are scored on a scale from 1 to 4, with higher scores reflecting greater cancer-related concerns [38]. Federal government websites often end in .gov or .mil. Stern A.F. [(accessed on 26 February 2022)]; Tuttle R.M., Tala H., Shah J., Leboeuf R., Ghossein R., Gonen M., Brokhin M., Omry G., Fagin J.A., Shaha A. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: Using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system. Addressing postoperative HrQoL when discussing therapeutic options with patients is an integral part of patient-centered care and informed shared decision-making, and should be approached in a holistic manner, accounting for its physical, psychological, social, and global aspects. Bongers P.J., Greenberg C.A., Hsiao R., Vermeer M., Vriens M.R., Lutke Holzik M.F., Goldstein D.P., Devon K., Rotstein L.E., Sawka A.M., et al. Your thyroid is a butterfly-shaped gland located in the front of your neck. Long-term quality of life in adult survivors of pediatric differentiated thyroid carcinoma. Quality of life after thyroid cancer surgery - American Thyroid Association Chan S., Karamali K., Kolodziejczyk A., Oikonomou G., Watkinson J., Paleri V., Nixon I., Kim D. Systematic review of recurrence rate after hemithyroidectomy for low-risk well-differentiated thyroid cancer.
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