probiotics for prediabetes

Dysbiosis of intestinal ecology could be implicated in prediabetes. If it goes unmanaged, prediabetes can lead to long-term damage, including to the heart and . Google Scholar. Front Pediatr. Three studies treated patients with only one probiotic, whereas the rest used combinations of three or more probiotics as interventions. Human studies have demonstrated the beneficial effects of probiotics, prebiotics, and synbiotics supplementation in prediabetes. This study was funded by the Key Laboratory of TCM Health Cultivation of Beijing, Beijing International Science and Technology Cooperation Base. [21] found that probiotics can promote glucagon-like peptide 1 (GLP-1) secretion from intestinal L cells to exert a hypoglycaemic effect. Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. American Diabetes Association: Standards of Medical Care in Diabetes 2019. Kim KN, Yao Y, Ju SY. Third, probiotics transform primary bile acids into secondary bile acids, which activate Takeda G protein receptor 5, after which they stimulate the secretion of GLP-1 [40]. 2014;13:398406. Forest plot of the effect of probiotics on QUICKI. 2012;379:227990. Nutrients. Fourth, probiotics reduce cholesterol absorption by converting cholesterol into faecal sterols via cholesterol reductase, which can be excreted in the faeces [51]. GLP1-derived nonapeptide GLP1(2836)amide protects pancreatic -cells from glucolipotoxicity. The supplementation of probiotic strain L. rhamnosus HN001 to pregnant women, starting from 14 to 16 weeks of gestation, reduced the risk of development of GDM, especially in older women with the previous history of GDM . A combination of probiotics and pre-biotics in the synbiotics supplementation is more effective than probiotics alone in glycemic control. Article Five studies contained HOMA-IR (Fig. The site is secure. The stepwise procedure of the selected studies was shown in the flow diagram of Figure 2. 2016;8:43. Lactobacillus could also transfer drug-resistant genes to pathogenic bacteria via splice plasmids or transposons, triggering genetic mutations and causing disease [90]. government site. In the gut microbiome, XOS can decrease or reverse the increase in abundance of Howardella, Enterorhabdus, and Slackia, which were observed to be higher in pre-diabetic patients. (37) showed that no difference was observed in the markers of glycemic control between the two groups after the 4-month intervention, although a minor effect was observed for fasting glucose at 1-month, probably due to the initial higher adherence to the probiotic supplements. 10). J Transl Med 20, 498 (2022). It is worth mentioning that leptin may act in both directions with insulin, which promotes the secretion of leptin; in contrast, leptin exerts a negative feedback regulation on the synthesis and secretion of insulin. By using this website, you agree to our Ahl D, Liu H, Schreiber O, Roos S, Phillipson M, Holm L. Lactobacillus reuteri increases mucus thickness and ameliorates dextran sulphate sodium-induced colitis in mice. 2014;39:127685. Last, probiotics inhibit the resynthesis of cholesterol through their production of short-chain fatty acids [17]. Nutrients. Chronic low-grade inflammation is an important pathological change in the progression of diabetes [41]. Effect of Lactobacillus casei strain Shirota-fermented milk on metabolic abnormalities in obese prediabetic Japanese men: a randomised, double-blind, placebo-controlled trial. Li Y, Wang DD, Chiuve SE, Manson JE, Willett WC, Hu FB, et al.. Dietary phosphatidylcholine intake and type 2 diabetes in men and women. In our systematic review, probiotics were found to reshape intestinal flora homeostasis to improve the digestion and absorption of nutrients in the intestine. Probiotics are a group of active microorganisms that primarily colonize the hosts intestinal and reproductive tracts, improve the bodys microecological balance and, when supplemented in sufficient quantities, exert beneficial effects on the enteric tract. Safety of probiotics in patients receiving nutritional support: A systematic review ofcase reports, randomized controlled trials, and nonrandomized trials.Am. Probiotics could increase the secretion of GLP-1 in the body. For example, Collinsella aerofaciens in the intestine increases intestinal permeability and is involved in proinflammatory processes through the production of the proinflammatory cytokine interleukin-17A; Firmicutes increases LPS levels in the intestine and accelerates the inflammatory response; and Butyrivibrio crossotus is involved in intestinal inflammation by activating rapamycin complex signalling [25]. No heterogeneity was detected between the two groups (I2=0%, P=0.42). The most critical thing is being able to stick to whichever diet you pick, so its important to find something that works for your lifestyle, your tastes and your preferences, Zumpano says. (36) found that compared to placebo group, GOS group can affect the abundance of different microbiome populations including increased Bifidobacterium, Prevotella oralis et rel., Prevotella melaninogenica et rel. 2020 Dec;49(4):67993. An elevated abundance of intestinal flora is associated with remission of diabetes. Proinflammatory cytokines can induce insulin receptor substrate-1 serine phosphorylation and block the insulin signalling pathway [42]; thus, they are considered the dominant factor in the development of insulin resistance [43]. Expert consensus on. Horm (Athens). 2021;44:72632. There was also no heterogeneity. BMJ. Apart from that, Bifidobacterium and Streptococcus bacteria have also been identified as having the ability to lower cholesterol levels [52]. Torres S, Fabersani E, Marquez A, Gauffin-Cano P. Adipose tissue inflammation and metabolic syndrome. Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al.. Metabolic endotoxemia initiates obesity and insulin resistance. Orellana-Gavalda JM, et al. 2010;1:18996. Springer Nature. Gut microbiota in 2012: toward understanding and manipulating the gut microbiota. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al.. Alisi A, Bedogni G, Baviera G, Giorgio V, Porro E, Paris C, Giammaria P, Reali L, Anania F. Nobili, V. Randomised clinical trial: The beneficial effects of VSL#3 in obese children with non-alcoholicsteatohepatitis.Aliment. Probiotics, prebiotics, and synbiotics supplementation in prediabetes Hepatology. But it does mean eating less of them. However, there is insufficient evidence to show significant benefits on glucose metabolism, lipid metabolism and body composition. Forest plot of the effect of probiotics on LDL-C. Forest plot of the effect of probiotics on HDL-C. Snchez B, Delgado S, Blanco-Mguez A, Loureno A, Gueimonde M, Margolles A. Probiotics, gut microbiota, and their influence on host health and disease. Boutant M, Ramos OH, Tourrel-Cuzin C, Movassat J, Ilias A, Vallois D, et al. Meanwhile, the prevalence of pre-diabetes can be inferred by IGT because it is a unified item in all diagnostic standards. Type 2 diabetes (T2D) is the primary type of diabetes, accounting for ~90% of all cases. Chinese Medical Association Diabetes Branch. Palacios T, Vitetta L, Coulson S, Madigan CD, Lam YY, Manuel R, et al. But theres good news: Type 2 diabetes isnt inevitable after youve been diagnosed with prediabetes. Bethesda, MD 20894, Web Policies Eur J Clin Nutr. However, there are a few important limitations that need to be acknowledged. Google Scholar. The supplementation of probiotics can suppress the rise of blood cholesterol, but the improvement cannot be verified. We aimed to systematically evaluate the effects of. Stefanaki et al. Kassaian et al. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Effect of multispecies probiotic supplements on metabolic profiles, hs-CRP, and oxidative stress in patients with type 2 diabetes. Leptin synthesized by gastric chief cells indirectly regulates the early secretion of GLP-1 through gastrin-releasing peptide [66]. Landis GN, Tower J. Superoxide dismutase evolution and life span regulation. We do not endorse non-Cleveland Clinic products or services. Standardized mean differences were chosen when the units and measurement methods of each indicator in the included studies were not consistent; conversely, weighted mean differences were chosen. 2014;63:72735. Introduction Mol Cell Biol. 2014;57:17695. Roy et al. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Multiple articles in this systematic review have reported that probiotics can reduce inflammation levels and improve insulin sensitivity in the following ways. No significant differences were found between the two groups (MD, 2.05; 95% CI -0.28, 4.38; P=0.08). This may suggest that probiotics could treat obese children by increasing GLP-1 secretion in vivo. 2020 Aug 27;56(9):433. Alcoholic beverages are a form of carbohydrate and should be consumed in moderation in general, and especially if youve been diagnosed with prediabetes. As a result, pre-biotics do not promote human nutrition, but they can produce beneficial metabolism and health benefits for the host [63). Meanwhile, synbiotics have been observed to have a more significant effect on blood glycemic control and inflammation than the use of probiotics alone (86). Short Chain Fatty Acids and Fecal Microbiota Abundance in Humans with Obesity: A Systematic Review and Meta-Analysis. 2007;73:17985. Articles that met the following requirements were excluded: study protocols, full text not available, and not in English or Chinese. A total of 6 studies reported FBG (Fig. 2018;215:38396. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. Li, Y., Wu, Y., Wu, L. et al. 2013;58:1207. Eating protein at every meal can help you feel full and reduce the urge to snack. 5). Mech Ageing Dev. Further experimental studies are needed to explore more other beneficial probiotic strains in humans and their quantitative-effect relationships to better define their role in prediabetes. PubMed Terms and Conditions, Shanghai Med. Gut. However, Baugh et al. and Butyrivibrio crossotus following probiotics were observably reduced, and both were implicated in hyperglycaemia and insulin resistance [25]. The seven types of bias listed in the manual are selection bias, allocation concealment, implementation bias, measurement bias, follow-up bias, reporting bias, and others. Four articles examined TC (Fig. The https:// ensures that you are connecting to the Slight heterogeneity was found (I2=6%, P=0.38). Previous studies suggest that gut microbiota plays an important role in the development of insulin resistance and diabetes mellitus (9). Stefanaki C, Michos A, Mastorakos G, Mantzou A, Landis G, Zosi P, et al. Nutrition. statement and The study screening process is shown in Fig. The PICO principle was adopted in this paper, namely, participants, intervention, comparison, and outcome. Stefanaki C, Michos A, Mastorakos G, Mantzou A, Bacopoulou F. Probiotics in adolescent prediabetes: a pilot RCT on glycemic control and intestinal bacteriome. Probiotics for the treatment of type 2 diabetes: A review of - PubMed Received 2020 Dec 22; Accepted 2021 Mar 3. [25] found that probiotics not only decrease the levels of lipopolysaccharide (LPS) and proinflammatory cytokines to increase insulin sensitivity but also reduce the abundance of harmful flora related to insulin resistance and the inflammatory response. The possible relationship between gut microbiota and pre-diabetes is shown in Figure 1. On the contrary, FXR activation suppresses the pre-proglucagon gene expression and GLP-1 secretion by inhibiting glycolysis and ChREBP activity in L-cells (27). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Sicard JF, Le Bihan G, Vogeleer P, Jacques M, Harel J. Interactions of intestinal bacteria with components of the intestinal mucus. Details are presented in Table1. XW and JY conceived the idea and drafted the initial manuscript. Therefore, in future researches, more and larger studies should be conducted to provide favorable evidence for -biotics to improve pre-diabetes, thereby providing a new therapeutic tool to prevent and delay the development of pre-diabetes to T2D. Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. The effects of probiotic supplementation on markers of blood lipids, and blood pressure in patients with prediabetes: a randomized clinical trial. 2015;15:40817. Nutrients. Darby TM, Naudin CR, Luo L, Jones RM. A high-fat diet can increase the percentage of Gram-negative species in gut microbiota (19). However, the disadvantage of using synbiotics is that it is difficult to predict the selectivity and specificity of each component and what the resulting mechanism of action will be. All authors agreed to publish the manuscript. Yeast fungemia is regarded as the most serious infectious complication caused by probiotics [88, 89]. Br J Nutr. Third, probiotics can also incorporate cholesterol into their cell membranes to lower blood cholesterol levels [50]. In addition, based on existing studies, we concluded that probiotics may regulate blood glucose homeostasis in a variety of ways. The prevalence of diabetes remains increased, with an estimated 463.0 million adults aged 2079 years, and the number is expected to reach 578.4 million in 2030 (1). Federal government websites often end in .gov or .mil. All Rights Reserved. Naito et al. In our systematic review, probiotics were found to increase GLP-1 secretion in vivo, which is essential for promoting insulin secretion through the action of intestinal proinsulin. Based on the evidence reviewed, multistrain probiotics that contain seven million to 100 billion colony forming units of Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus, and/or Bifidobacterium lactis administered for 6 to 12 weeks may be efficacious for improving glycaemic control in adults with T2DM. Prediabetes and Probiotics - Humarian [67] observed that supplementation with oral Lactobacillus rhamnosus GG induced elevated leptin levels dependent on functional Nox1 protein in the intestine. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Probiotics exert beneficial effects on the body by regulating the intestinal microbiota [11]. Probiotics in adolescent prediabetes: a pilot RCT on glycemic control and intestinal bacteriome. PubMed Prediabetes - Diagnosis and treatment - Mayo Clinic Studies have shown that gut microecosystems are distinct between healthy individuals and diseased individuals and that dysregulation of the intestinal flora is associated with metabolic diseases such as hyperglycaemia and obesity [20, 26, 27]. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. To prevent prediabetes from progressing to type 2 diabetes, try to: Eat healthy foods. Do Probiotics Improve the Health Status of Individuals with Diabetes 2020;125:109914. YW and YL analysed the data. Human studies have demonstrated the beneficial effects of probiotics, prebiotics, and synbiotics supplementation in prediabetes. CAS Finally, probiotics can reduce the activity of enzymes related to reactive oxygen species (e.g., cytochrome P450 enzymes and NADPH oxidase) [66]. 8). This paper has shown that probiotics could significantly reduce HbA1c, QUICKI, TC, TG and LDL-C in patients with prediabetes. But, they are an effective approach in type 2 diabetes mellitus patients to promote better metabolic control and improve dyslipidemia. Scientists are testing many different supplements to. This work is supported by the Applied Basic Research Program (2019YJ0657) from the Department of Science and Technology of Sichuan Province. This meta-analysis was performed using Review Manager 5.4. Eslamparast T, Zamani F, Hekmatdoost A, Sharafkhah M, Eghtesad S, Malekzadeh R, et al.. Four articles addressed TG (Fig. The fiber in veggies and legumes will help you feel full and satisfied.. Another pilot study (37) conducted by Stefanaki et al. Mouzaki M, Comelli EM, Arendt BM, Bonengel J, Fung SK, Fischer SE, et al. Nat Commun. A study (73) has reported that Lactobacillus acidophilus DSM20079 induced 14.5-fold more butyrate in the presence of inulin or pectin than in the presence of glucose. official website and that any information you provide is encrypted J Pediatr. In 2019, the International Diabetes Federation (IDF) reported that 7.5% of the adult population, 373.9 million adults aged 2079 years, are estimated to have IGT. Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, et al.. Role of gut microbiota in type 2 diabetes pathophysiology, Gut microbiota, prebiotics, probiotics, and synbiotics in management of obesity and prediabetes: review of randomized controlled trials. Pre-biotics are non-digestible food ingredients that can be obtained from fruit, vegetables, cereals, and other edible plants. We searched for EMBASE, MEDLINE, Web of Science, Cochrane Central, Clinical Trials (ClinicalTrials.gov) from inception to February 2021. Famouri F, Shariat Z, Hashemipour M, Keikha M, Kelishadi R. Effects of probiotics on nonalcoholic fattyliver disease in obese children and adolescents.J. This study provides valuable references for subsequent related studies and future clinical translation. Mol Nutr Food Res. Acta Diabetol. Jams and jellies. 2000;28:145662. A diet high in fruits, vegetables, nuts, whole grains and olive oil is associated with a lower risk of prediabetes. Certain species of probiotics could reinforce the mucus barrier by increasing the expression of mucin genes and stimulating mucus secretion [53]. Load up on vegetables, particularly non-starchy ones, Zumpano says. Benef Microbes. Finally, some basic experiments are needed to elucidate more clearly the mechanism of probiotic action on prediabetes at the molecular level. These populations are reported to associate with obesity (57), insulin resistance (58), gut permeability (59), and anti-inflammation (60). The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review. (52) carried out a study that included probiotics, synbiotics and placebo group and published different outcomes on metabolic syndrome, lipid profiles (53), glucose and insulin metabolism (54) and gut microbiota (55). In this light, we further systematically reviewed the mechanisms of action and side effects of probiotics in prediabetes. 2021 Jan 12;8:581461. doi: https://doi.org/10.3389/fped.2020.581461. First, probiotics are able to produce short-chain fatty acids (SCFAs) by fermenting dietary fibre from the diet, which can promote GLP-1 production [38]. Inflammatory components of adipose tissue as target for treatment of metabolic syndrome. That does just mean saying see ya to soda. It is also worth stating that other toxicological effects of probiotics have been found in previous studies [86, 87]. 1991;4:33944. In this light, there is an urgent need for natural and safe strategies to control and delay the progression of prediabetes to diabetes [6].
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