All rights reserved. Although the research on this topic is limited to mostly animal studies, one trial published in Photochemistry and Photobiology found that silymarin protected the skin of mice from UV-induced oxidative stress and helped reduce inflammation. Its loaded with medicinal compounds, including saponins, isoflavonoids, and polysaccharides, which have powerful therapeutic properties (56). When fatty liver is caused by heavy alcohol use, it is called alcohol-associated liver disease. Prickly yet pretty, milk thistle is a plant with a long, thin stem, spiny leaves, and a purplish-pink thistle at the top. These unstable molecules are byproducts of your bodys functions. Milk thistle is often promoted for its liver-protecting effects. https://www.micromedexsolutions.com. Turmeric is generally considered safe, but some cases of liver injury have been reported. You can also grow your own milk thistle and make homemade tea if youre up for harvesting the plants. However, there is no solid evidence that supports these claims. In fact, it has traditionally been used to treat liver and gallbladder disorders, promote breast milk production, prevent and treat cancer and even protect the liver from snake bites, alcohol and other environmental poisons. 2023 Healthline Media LLC. https://www.nccih.nih.gov/health/milk-thistle. The right supplements can help bring your body back into balance while it heals. We found no reduction in mortality, in improvements in histology at liver biopsy, or in biochemical markers of liver function among patients with chronic liver disease. Other imaging tests, such as MRI, CT and ultrasound, also may be done. Nonalcoholic fatty liver disease & NASH. When you just have excess fat stored in your liver, it is referred to as nonalcoholic fatty liver (NAFL). Another study in 70 people with NAFLD found that those who supplemented with 500 mg of curcumin and 5 mg of piperine per day for 12 weeks had significant reductions in ALT, AST, LDL (bad) cholesterol, and inflammatory markers, compared with a placebo group (39). However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. To begin the healing process, use a fish oil supplement. information and will only use or disclose that information as set forth in our notice of Liver cleanse drinks are touted to improve liver health, remove waste and toxins, and boost your energy. Osteoporosis is a disease caused by progressive bone loss. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Its responsible for most of the deaths from eating foraged mushrooms worldwide each year. Milk thistle may be useful in treating liver disease, cancer, and diabetes. Milk thistle is a plant named for the white veins on its large prickly leaves. Although its generally safe, you should talk to your doctor before starting supplementation if you are taking any medications or experience side effects like digestive distress. Wah Kheong C, Nik Mustapha NR, Mahadeva S. A randomized trial of silymarin for the treatment ofnonalcoholic steatohepatitis. Summary One study has shown that people taking milk thistle supplements experienced a decrease in the number of acne lesions on their body. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (Nashfit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH. It now grows all over the world, including northern Africa, South Australia, and parts of North and South America. In the context of studies on NAFLD, moderate exercise is often considered to be five exercise sessions per week of 30 minutes at your target heart rate, with a 10-minute warm-up and a 5-minute cool-down at 30% to 40% of your target heart rate. People mainly use the supplement to treat liver conditions. If you are taking any medications, speak with your health care provider to prevent any milk thistle interactions before starting supplementation. The silymarin found inmilk thistle can also protect against depletion of glutathione, which is a master antioxidant thats extremely useful at helping prevent disease formation. But is it really good for you, and can it really help your liver? More studies are needed before it can be determined how silymarin might be used to support people undergoing cancer treatment. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). Liver disease is treated in a number of ways, including medication, nutritional therapy, immunotherapy, lifestyle change, surgical resection, and even liver transplant in end stage liver disease (6, 7, 8, 9). When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). However, results from human studies have been mixed (12). Milk thistle can cause an allergic reaction, especially if youre allergic to other plants in the same family. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. However, human studies are limited and havent yet shown any beneficial effects. To make it taste better, drop the liquid into a fruit smoothie. However, while there are many different potential benefits, it is most well-known for being a natural liver supporter and is sometimes used to help treat liver diseases such as cirrhosis, jaundice and hepatitis, as well as gallbladder problems. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Diabetes and Liver Cancer: What Is the Relationship? The apple cider vinegar was said to help "soften liver stones". Fall 2019. Silymarin is believed to have antioxidant properties. The liver is a major digestive organ, which helps process nutrients and toxins that enter our body through foods, water and air. Yum! Yes, fatty liver can be reversed or at least controlled, but the treatment will vary based on the cause. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. It also encourages bile flow from . Although there is no standardized milk thistle dosage at this time, most people do best consuming between 20300 milligrams daily. Silymarin in treatment of non-alcoholic steatohepatitis: A randomized clinical trial. Fortunately, some of this damage appears to be reversible if you take off the extra pounds. Milk thistle seems to have few side effects, even when taken for several years. are clickable links to these studies. National Center for Complementary and Integrative Health. Due to its antioxidant and anti-inflammatory effects, milk thistle may be a useful supplement for people with acne. Medical research on milk thistle and liver health has led to mixed results. Supplementing with turmeric and curcumin is generally considered safe. In: Textbook of Natural Medicine. Milk thistle is an herbal remedy with many potential uses. Practical dietary recommendations for the prevention and management of nonalcoholic fatty liver disease in adults. It helps rebuild liver cells while removing toxins from the body that are processed through the liver. In the glycyrrhizin group, these markers did not significantly increase, suggesting that glycyrrhizin may help protect against alcohol-related liver damage (35). People with NAFLD who supplemented with 2 grams of ginger for 12 weeks experienced significant reductions in ALT, GGT, inflammatory markers, and fat accumulation in the liver, compared with a placebo group (47). Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. If you have diabetes, controlling its symptoms can also reverse liver fat buildup. Use 5-7 drops 1x per day. This may be because of its anti-inflammatory effects or because it inhibits the deposition of fat in the liver. Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Milk thistle. Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. George ES, Forsyth A, Itsiopoulos C, et al. In addition to its direct anticancer effects, milk thistle silymarin compounds may also reduce damage to the heart and liver from chemotherapy drugs. Accessed Oct. 30, 2020. Milk thistle is effective at naturally reversing toxicity in the body, including the harmful effects of alcohol consumption, pesticides in our food supply, heavy metals in our water supply and pollution in the air that we breathe. It's estimated that rates of NAFLD may be 90% in obese people and 50% in people with diabetes. 12. Its anti-inflammatory and antioxidant properties mean that it is possibly neuroprotective and could help prevent the decline in brain function you experience as you age (14, 15). There is also concern that milk thistle might affect estrogen levels. 1. 2014;5(1):9-12. Eating raw garlic twice or more per week was associated with a 23% reduced risk of liver cancer, compared with consuming raw garlic less than twice per week (44). Its well documented that turmeric has powerful anti-inflammatory, antioxidant, and anticancer properties, which makes this herb a popular choice for those with liver disease (37). Although raw garlic intake was inversely associated with NAFLD in men, this association was not seen in women (43). Accessed Oct. 30, 2020. Ginger is generally considered safe. While not dangerous, it can cause scars. Licorice root has been shown to have anti-inflammatory, antiviral, and liver-protective effects in scientific studies (33). However, some cases of acute liver injury have been reported. Milk thistle may be a useful complementary therapy to help manage type 2 diabetes. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). Milk thistle may help protect the liver against damage from exposure to industrial toxins. Milk thistle is generally considered safe and well-tolerated, with very few cases of side effects reported. Although these findings are promising, more research is needed. IBM Micromedex. Written by Angela Nelson Medically Reviewed by Minesh Khatri, MD on August 31, 2022 Supplements & Your Liver Prickly yet pretty,. Foods with high amounts of sugar or alcohol can contribute to fatty liver disease. Some people have nausea, diarrhea, itching, and bloating. In addition to standard treatments, many people turn to alternative therapies, including herbal supplements, in hopes of improving and protecting their liver health. Here are the 10 best herbs that have been shown to improve liver health. Certain herbs have been associated with improved liver health, making them a popular natural remedy choice for those with liver conditions, as well as those who want to support their liver health. Sticking to a healthy, plant-based diet and getting regular exercise can keep fat from building up in your liver. In the July 2007 issue of "American Journal of Physiology, Cell Physiology, scientists propose that the key to reducing liver cysts is to prevent the abnormal growth of epithelial cells by suppressing vascular endothelial growth factor. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Something important to keep in mind, however, is that existing studies on possible heart benefits of milk thistle have only been done involving people with diabetes, who tend to have high cholesterol levels. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Often considered a weed, it has been used for hundreds of years as a natural, herbal way to treat liver and gallbladder diseases. A major study found that people with hepatitis C didnt benefit even from higher-than-normal doses of silymarin. The liver is actually our largest internal organ and is responsible for performing a number of essential detoxifying functions. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. According to a study published in the "Journal of Ethnopharmacology in August 2010, dandelion demonstrates anti-fibrotic properties and promotes the regeneration of liver cells in mice. Liver cysts are fluid-filled sacs that do not require treatment unless symptoms develop, such as abdominal bloating or pain. Copyright 2023 Leaf Group Ltd., all rights reserved. If you want to detox, try taking a week to reset your eating habits by eating only whole, unprocessed foods including lots of fresh fruits and vegetables, whole grains, healthy oils, lean proteins, and low-fat dairy. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). In fact, herbal medicines have been associated with liver damage and even death. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Green tea and green tea extract have been linked to powerful liver-protective effects. 2017;15(12):1940-1949.e8. 2020;18. doi: 10.1016/j.conctc.2020.100560, Wijarnpreecha K, Thongprayoon C, Ungprasert P. Coffee consumption and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Milk thistle ( Silybum marianum ) is a flowering plant that comes from the same family . It promotes cellular repair and regeneration. Keeping fatty liver in check is crucial to your overall health; excess liver fat can make you more vulnerable to cardiovascular disease, in addition to liver disease and diabetes. Artichoke leaves and roots contain compounds that stimulate bile flow and reduce fat concentration. Your liverac." Dr. Vincent Esposito on Instagram: "Everything you put in your body must go through the liver at one point or another. In fact, many companies make milk thistle tea by steeping the leaves and seeds from the plant. Other people have reported a headache or itchiness after they take it. Hepatitis Reference Does Milk Thistle Help Your Liver? This is because many herbal treatments have been shown to be toxic to the liver and may be dangerous to take, especially for those with liver diseases or other medical conditions (61). Because the liver and other digestive organs, like thegallbladder, pancreas, intestines and kidneys, work closely togethertoimprove liver health, milk thistle is also able to help prevent gallstones and kidney stones. Finally, keep in mind that, although many holistic practitioners recommend milk thistle for dogs to help promote liver health, its best to talk to your vet before starting supplementation to keep your furry friends safe. In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). Every year, liver disease accounts for nearly 2 million deaths worldwide (2, 3). Milk thistle benefits heart health and helps lower highcholesterollevels by reducing inflammation, cleaning the blood and preventing oxidative stress damage within the arteries. Nonalcoholic fatty liver disease. Risk factors for liver disease include heavy alcohol intake, high blood sugar levels, obesity, high blood pressure, viruses, elevated triglyceride and cholesterol levels, and more (4, 5). Taking ginger supplements may help reduce liver damage and lower cholesterol, blood sugar, and inflammation in people with NAFLD. Because milk thistle is categorized as a supplement rather than a drug, its not subject to the same oversight and quality control from the Food and Drug Administration (FDA) that standard drugs are. Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (Nashfit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH. A number of test-tube and animal studies have demonstrated that ginseng has antioxidant effects and may help protect against liver injury caused by viruses, toxins, and alcohol. Ginseng is a popular herbal supplement known for its powerful anti-inflammatory properties (20). ( 94 , 146-148) All rights reserved. Consult your physician before taking milk thistle if you take other medicines because this herb may interfere with their metabolism in the liver. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. Each small plant head contains about 190 seeds that can be used in various ways. Levels of gamma-glutamyl transferase (GGT), another marker for liver damage, were also reduced significantly (24). Even though some medications may be hard on your liver, you should not stop any of your prescribed medications suddenly without talking to your healthcare provider. Researchers found no changes in virus levels or quality of life in people who took the milk thistle, compared with those who took a placebo. Transaminitis (Liver Enzyme) Result: Meaning and Causes, Practical dietary recommendations for the prevention and management of nonalcoholic fatty liver disease in adults. Its also known as St. Marys thistle, holy thistle and silybum. In addition to blocking breast cancer, test-tube and animal studies show that silmarin may also protect against several other types of cancer as well, including lung cancer and prostate cancer. Discuss all of your treatment options with your doctor before attempting self-treatment with complementary therapies. But the evidence is limited, and some research methodologies are flawed, so it's difficult to confirm these. Get 600mg a day. What to Eat When You Have Fatty Liver Disease. Diabetes and Liver Disease: What Is the Relationship? Keep the seeds and leaves in the freezer to make them last longer and retain their powerful nutrients. Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Even though liver cysts are benign and do not cause liver failure, they can signal the presence of an underlying disorder, such as polycystic liver disease or a parasitic infection. Consult your physician before using green tea if you take other medications to avoid interactions. include protected health information. Talk to your doctor before you take milk thistle. Milk thistle. Gallstones are formed when cholesterol and other matter within your bile bind together. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls. In the May 2010 issue of "Food and Chemical Toxicology, scientists discuss the effects of two polysaccharides from dandelion that significantly decrease the activity of certain enzymes responsible for producing inflammation and liver lesions. Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study. Our team aims to be not only thorough with its research, but also objective and unbiased. Non-alcoholic fatty liver disease and the Mediterranean diet. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). More research is needed, but both animal and human experiments have shown a lower prevalence of NAFLD in coffee drinkers. This applies to both the surface of your skin and your organs, as antioxidants can protect your body from chronic disease. 236 likes, 3 comments - Dr. Vincent Esposito (@drvincentesposito) on Instagram: "Everything you put in your body must go through the liver at one point or another. This powerful plant is native to the Mediterranean, but is used around the world as a natural remedy for a wide variety of different ailments. Eat a balanced diet that includes fiber and "good" fats, such as those found in nuts, seeds, and fish. The efficacy and safety of long-term vitamin E use has not been evaluated in people with diabetes or people without NASH confirmed in a biopsy.
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