The randomization list was not released until approval was received for the study to be unblinded for analysis. These authors declare no conflict of interest with regards to the present paper derived from the study, for which no compensation or stipend was received. All this the indications for which the use of funds for the treatment of the gastrointestinal tract. Book an appointment automatically - Get the personalized health, By clicking the Sign Up button or the submit button, I confirm that I have read and agree to the, Address: 458 Minh Khai, Vinh Tuy Ward, Hai Ba Trung District, Hanoi, Vietnam, Obstetrics & Gynecology and Assisted reproductive technology, Rights and responsibilities of patients and their families, Vinmec Research Institute of Stem Cell and Gene Technology, How to handle when children have diarrhea due to taking antibiotics, Different roles of zinc in immune responses, Treating bowel and urinary disorders with physiotherapy. This is explained by acute watery diarrhoea being self-resolving within seven days. In these three trials, median times to recovery were respectively: 45 hours 15 minutes in the placebo group versus 23 hours and 30 minutes in the 1mg loperamide group [27]; 34 hours 15 minutes in the placebo group versus 26 hours 30 minutes in the 1mg loperamide group [29]; 40 hours 35 minutes in the placebo group versus 27 hours 55 minutes in the 1mg loperamide group [28]. Anal irritation before inclusion was present in 18.1% of the patients in the diosmectite group and 24.5% in the placebo group. In adults, the treatment does not dispense with rehydration, if this is considered to be necessary. Also, not everyone knows how to drink Smecta, in what dosage. Nevertheless, a post hoc time to event analysis taking data censure into account was carried out. Acute watery diarrhoea is self-resolving, even in the absence of treatment. The 4 Best Options for OTC Diarrhea Relief In adults, no prospective, randomized, placebo-controlled trial on the efficacy of diosmectite in the treatment of acute diarrhoea has yet been conducted. The use of Linex is appropriate for rotavirus infection, after antibiotic therapy. Guideline for the management of acute diarrhea in adults. sharing sensitive information, make sure youre on a federal Diosmectite is a powder for oral suspension in a sachet, composed of 3.000g diosmectite, 0.004g vanillin, 0.007g sodium saccharin, and 0.749g glucose monohydrate. H. M.-Fortunet and P. Garnier are employees of Ipsen, the developer of diosmectite and owner of Smecta. Hughes IW. It should be noted that the use of Smekta is effective for rotavirus infection, which is difficult to treat in other ways. It is the medicine of choice for treating diarrhea in children. Smecta is a powder mass from which an oral suspension with different flavors is prepared - you can choose the taste of vanilla or orange. How to stop diarrhea fast: Methods and what to avoid - Medical News Today Except in chronic diarrhoea, trials performed in adults rarely use stool volume as an endpoint. Drugs Smecta: Effects, doses and precautions when used Function Dosage forms Dosage How to use Side effects Its effectiveness in improving stool consistency is the result of its ability to absorb bacteria, viruses and toxins as well as strengthening the intestinal mucus barrier to reduce luminal antigens passing through the mucus barrier which in turn helps to reduce inflammation. In the field of geology, it is more commonly known as montmorillonite; the name is a contraction of dioctahedral smectite. Children and infants: The content of the sachet may be mixed in a bottle of 50ml of water to be given during the day, or well mixed with a semi-liquid food, such as broth, compote, puree, baby food. Incidence decreased to <5% in both groups after 36 hours (N.S). Smecta is supplementary to dietary rules: In infants and children, oral rehydration solution (ORS) must be administered at the earliest in addition to Smecta to avoid dehydration. This study was sponsored by Ipsen. They have a similar effect, but they have unequal contraindications. What methods can help to stop diarrhea fast? The ITT population included randomized patients having taken the study drug at least once together with a primary endpoint that was assessable. Smectite is a natural medical clay, widely used in the treatment of acute diarrhoea in humans. Edited by FDA US Department of Health Education and Welfare; 1977: HEW (FDA) 78: 3049. 10 sachets Powder for oral administration Strawberry flavour. and transmitted securely. Fioramonti J, Fargeas MJ, Bueno L. Action of T-2 toxin on gastrointestinal transit in mice: protective effect of an argillaceous compound. As a library, NLM provides access to scientific literature. A flow chart of all the screened patients (n = 346) included and randomized to receive diosmectite (n = 173) or placebo (n = 173) is shown in Figure 1. The median number of stools per 12-hour period decreased from 3 at baseline to 1 at the 3648h period onwards with a significant difference in favour of diosmectite group at the 7284h period (P = .016). Therefore, it can be estimated that results of the present study can be extrapolated to western countries. This substance is a part of other drugs with a similar mechanism of action: There are also a number of other drugs with other active ingredients, but with a similar effect: What is better to choose with diarrhea - Smektu or Enterosgel? None of its components are absorbed into the bloodstream even with diseases such as colitis and colonopathy. Pepto-Bismol, on the other hand . In this case, the description of Smecta gives the following instructions for use for children: If a child had taken Smecta for a long time, you should take care of the treatment preventing dehydration of the body. 2022 EP Plus Group Sdn. The reasons may be different overeating, poisoning, dietary disorders, infection. Hombrick J. The drug is also used to treat symptoms in adult intestinal stimulation syndrome and gastroesophageal reflux in newborns due to its protective effect on the mucous membranes. Smecta : More than 40 years of experience in treating acute diarrhoea. The primary objective was to compare the efficacy of diosmectite to that of placebo in adults with acute watery diarrhoea, taking time to recovery as a primary endpoint. Instructions for use Smekty for diarrhea is attached. Diosmectite was well tolerated. Do not forget about the need to introduce a sufficient amount of fluid in the body. Be carefull though, as Smecta may cause dehydration in your baby. Diosmectite (brand names Smecta, Smecdral) is a natural silicate of aluminium and magnesium used as an intestinal adsorbent in the treatment of several gastrointestinal diseases, including infectious and non-infectious acute and chronic diarrhoea, including irritable bowel syndrome diarrhea subtype. We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Customers SHOULD NOT arbitrarily apply it at any circumstances. Take special care with Smecta and seek medical advice if: Smecta powder for oral administration Orange or Strawberry flavor: what you should know. Fendri C, Slim A, Arrouji Z, et al. Exceed the proposed dosage should not be allowed. The baseline clinical picture of acute diarrhoea episodes was not different between both groups (Table 1). For the convenience of users of the iLive portal who do not speak Russian, this article has been translated into the current language, but has not yet been verified by a native speaker who has the necessary qualifications for this. Methods. You have acute or chronic diarrhoea and the problem does not disappear within 7 days, Diarrhoea is associated with a high temperature, sudden weight loss or vomiting. for more information or register for an appointment HERE. Teens over 12 take 6 sachets per day for 3 days. Comparative efficacy of dioctahedral smectite (Smecta) and a Methods. Administration: The content of the sachet must be mixed in suspension directly before use. Patients were randomly treated with either diosmectite or placebo. Sometimes, several doses of activated charcoal are needed to treat severe poisoning. Avoid certain foods such as dairy products, fatty foods, high-fiber foods or highly seasoned foods for a few days. The contents of the sachet or pack should be diluted in a glass of 50 ml of water and taken orally. Meropol NJ, Blumenson LE, Creaven PJ. Loperamide: a medicine used to treat diarrhoea - NHS Smecta is a complementary medicine to assist in the management of acute diarrhoea. Antibiotic associated diarrhoea occurs in about 5-30% of patients either early during antibiotic therapy or up to two months after the end of the treatment. Smecta for children of 2 years and above. Fluid intake is to be maintained, preferably with glucose-containing drinks or electrolyte-rich soup, as indicated by thirst. All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible. It was a powder for oral suspension in a sachet, composed of 1.000g titanium dioxide, 1.181g maltodextrin (Roquette Glucidex IT 38), 0.004g vanillin, 0.007g sodium saccharin, 2.150g glucose monohydrate, and 0.018g caramel colouring E150B. Smecta slows down the absorption of alcohol from the blood, so when drinking alcohol intoxication occurs more slowly. Charcoal, Activated (Oral Route) Description and Brand Names The median [range] duration of exposure was 4.2 days [0.37.5] in the diosmectite group and 4.2 days [010.1] in the placebo group. Acute diarrhoea is one of the leading causes of morbidity worldwide [1]. However, it should be understood that not all sorbents are as effective and selective in their action as Smecta. Recalls Certain Pilot COVID-19 At-Home Tests for Potential Bacteria Contamination. Given this, it is allowed for use during pregnancy, but only at doses recommended for adult use by patients. Oral rehydration solutions are needed in frail people only. The information published on the portal is for reference only and should not be used without consulting a specialist. For chronic diarrhoea in adults, the dosage is of an average of 3 sachets per day. If Smektu is taken for the treatment of esophagitis, then the reception is performed after eating. Its absence of pharmacological activity was demonstrated on an animal model of watery diarrhoea (data not shown). How Do You Make A Smecta Sachet? But the indications for taking Fosfalugel are more extensive: gastric ulcer and duodenal ulcer, gastritis, diaphragmatic hernia, diarrhea, functional disorders, heartburn, "sour" burp, swelling, etc. Newly diagnosed ambulatory patients suffering from acute diarrhoea presumed to be of infectious origin were randomized to receive diosmectite or placebo. Structural features of the drug do not allow the drug to be absorbed and metabolized in the body. In contrast, another 5 of these 47 patients had major protocol deviations due to poor observance as a consequence of early recovery. Thielman NM, Guerrant RL. Costs associated with office visits for diarrhea in infants and toddlers. You'll stop taking Lomotil once your diarrhea is completely gone. First, Smecta fills minor defects in the mucous membrane and forms a protective layer on its surface. Smecta is a combined silicate with magnesium and aluminum. Like other adsorbents, diosmectite is not absorbed in the intestine. The objective of this study was therefore to assess the efficacy of diosmectite on the time to recovery in adults with acute diarrhoea. Over-the-counter anti-diarrheal medications, such as loperamide and bismuth subsalicylate, might help reduce the number of watery bowel movements and control severe symptoms. In children, diosmectite efficacy in the treatment of acute watery diarrhoea has been assessed in a recent meta-analysis. Activated charcoal has not been shown to be effective in relieving diarrhea and intestinal gas. Such a means is "Smecta. Vinmec is not responsible for any cases of self-application without a doctor's prescription. Bethesda, MD 20894, Web Policies Therefore, their effectiveness is equivalent. The site is secure. Do not cook in aluminum foil and this is why, Bacterial infections, including those of unclear origin, Digestive disorders in gastric ulcer, gastritis, isophagitis, duodenitis, cholecystitis, colitis. Per-protocol (PP) population included ITT patients without major protocol deviations as defined after a blind review. The special crystal structure of these compounds gives them the ability to envelop all pathogenic viruses, bacteria and their toxins and removes them from the gastrointestinal tract in a natural way along with feces. The median number of watery stools decreased from 2 at baseline to 0 at the 1224h period onwards (N.S). In pregnancy, the drug is quite possible, but they should not be treated for longer than three days. Placebo was inert and identical to diosmectite in size, weight, colour, smell, taste, and appearance, either as a powder or a water solution. Copyright 2011 - 2022 iLive. The active substance in SMECTA is diosmectite, a natural clay processed and purified for therapeutic use. The contents of the sachet must be mixed in half a glass of water before its administration. Smecta with diarrhea comes into contact with glycoproteins of mucous tissues and provides increased mucous protection from irritants. Five of these patients had prematurely stopped treatment because of a perfectly documented recovery. The percentage of therapeutic success, defined as patients having achieved the primary efficacy endpoint, per cumulative 12-hour period, was higher in the diosmectite group than in the placebo group in the following periods: 036h (28.5% versus 19.2% [P = .055]); 048h (43.7% versus 29.5% [P = .009]); 060h (52.5% versus 41.0% [P = .041]); 072h; 60.8% versus 50.0% [P = .055]) (Figure 2). The use of Smecta above the recommended amount can lead to the development of constipation or the formation of bezoar stone in the stomach. Smecta sachet is used for the treatment of acute and chronic diarrhea. Preference should be given to low-fat boiled meat, dishes from rice cereals. In accordance with the protocol, the PP population excluded patients with major protocol deviations including patients who recovered early and, as a consequence, prematurely stopped their treatment. This corresponds to respective decreases of 21 hours, 12 hours 40 minutes, and 7 hours 45 minutes with loperamide, which can be considered to be a similar range to the results observed here with diosmectite. Single cases of allergies during the use of the medication manifested itself by such symptoms as skin rash, itching, swelling. The https:// ensures that you are connecting to the So, Smecta is an enterosorbent, and Phosphalugel is not only a sorbent, but also an acid neutralizer, and an astringent preparation. 8600 Rockville Pike You should also not take medicine in case of intolerance to its components. Guidelines for the clinical evaluation of antidiarrheal drugs. Smecta with strong diarrhea also demonstrates the therapeutic effect: the intestinal microflora is normalized, the stool is fixed, nausea and unpleasant sensations in the abdominal region pass. {"type":"clinical-trial","attrs":{"text":"NCT00276328","term_id":"NCT00276328"}}. However the absorbing characteristics of diosmectite can disturb the absorption rates of other substances. Garthright WE, Archer DL, Kvenberg JE. Chang FY, Lu CL, Chen CY, Luo JC. In addition, the drug has a beneficial effect on the gastric mucosa. Diarrhoea is a common adverse effect of antibiotic treatments. Conclusion. There was no difference between groups with regards to age, gender distribution, height, and weight, previous medical history (222/329 or 67.5% of the patients had no medical history) and concomitant treatments.