View abstract. Using human neutrophils, the extract demonstrated inhibitory activity against platelet activating factor24, which is a known mediator of UVB-induced immunosuppression.25 The specific compound responsible for this effect has been identified as 1,2-di-O-palmitoyl-3-O-(6-sulpho-alpha-D-quinovopyranosyl)-glycerol26. Polypodium leucotomos has benefits for hyperpigmentation, according to a clinical trial published in the Journal of Drugs in Dermatology in 2019, which showed that it may be used as an adjuvant treatment to traditional means of photoprotection against the effects of visible light-induced pigmentation. J Am Acad Dermatol. Photodermatol Photoimmunol Photomed 1997;13:50-60. 2014 Jul;23(7):526-8. doi: 10.1111/exd.12454. Polypodium leucotomos | DermNet Polypodium leucotomos is a tropical fern from Central and South America. The fern is also found in creams and ointments, but research on the safety and efficacy of these products is currently unavailable. Polypodium Leucotomos Extract 240mg 200 Veggie Capsules (Vegetarian P. leucotomos treatment of human fibroblasts had a protective effect on the morphological changes that occur following UV exposure. Morgado-Carrasco D, Granger C, Trullas C, Piquero-Casals J. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Parrado C, et al. J Am Acad Dermatol 2004;50:41-9. [5] [6] A review of 19 human and 6 basic scientific studies showed that Polypodium leucotomos was well tolerated with a favorable side effect profile. The effect of polypodium leucotomos on hair lies in its antioxidant properties and ability to fight free radicals which in turn detoxifies the hair and boosts its health. Garcia F, Pivel JP, Guerrero A, et al. PLE is a natural extract that comes from a South American fern, and is packed with antioxidants that help skin to naturally protect itself from UV damage. 2014 Feb;13(2):148-53. Upregulation of Cox-2 is associated with UV-induced skin cancer12,13. Jamgochian M, Alamgir M, Rao B. As Downie told HuffPost, there are a number of pills marketed as sunscreen pills that really dont protect people from the sun. Early research suggests that taking Polypodium leucotomos extract might reduce, Dark skin patches on the face (melasma). Gonzalez S, Pathak MA, Cuevas J, et al. It is also used for other cancers and Alzheimer's disease. Another study in 57 adults who typically developed skin rashes after sun exposure found that over 73% of participants reported significantly less inflammatory reactions to the sun after taking 480 mg of Polypodium leucotomos daily for 15 days (14). In 1999, the antioxidant and photoprotective properties of P. leucotomos extract were demonstrated when applied topically to hairless mice exposed to UVB radiation10. Both its thin, green leaves and underground stems (rhizomes) have been used for medicinal purposes for centuries (1). It grows in varied habitats in Florida, including swamps and hammocks, and can thus apparently tolerate a wide range of microclimates. 1981;72(9-10):487-494. [3] This study isolated a triterpenoid glycoside from the mashed and dried rhizomes and was named Calagualine in honor of the common name of Polypodium Leucotomos, Calaguala. Decoctions have been used as a panacea in Central American folk medicine. 8600 Rockville Pike Polypodium leucotomos as an Adjunct Treatment of Pigmentary Disorders New oral and topical approaches for the treatment of melasma Berman B, et al. Polypodium leucotomos (Phlebodium aureum) is a tropical fern that belongs to the Polypodiaceae family.. There is abundant evidence that UVB radiation-induced immunosuppression is a major contributing factor to UVB-induced skin cancers in mice15. Ramrez-Bosca A, Zapater P, Betlloch I, et al. By entering your email and clicking Sign Up, you're agreeing to let us send you customized marketing messages about us and our advertising partners. Phlebodium aureum - Wikipedia Information from this source is evidence-based and objective, and without commercial influence. With these pills, people feel like they can pop a pill, not put on sunblock at all, and thats completely dangerous and completely false [especially] with incidents of skin cancer rising the way it has been., What these sun protection supplements do on a cellular level, Nazarian explained to HuffPost, is curb some of the inflammation and some of the damage that was done to cells., But, she stressed, theyre not sunscreen. Pretreatment with P. leucotomos was cytoprotective against UV-induced damage resulting in increased cell survival. In one study, animals received an oral extract of P. leucotomos (~300 mg/kg) for 5 days prior to UVB (equivalent to 11.5 times the minimal erythema dose [MED] and for 2 days afterward. Is Polypodium leucotomos effective in treating Melasma? J Eur Acad Dermatol Venereol. Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines. PMID: 31859468. Caccialanza M, Percivalle S, Piccinno R, et al. Ahmed AM, Lopez I, Perese F, et al. Learn how and when to remove this template message, "Polypodium leucotomos as an Adjunct Treatment of Pigmentary Disorders", "Polypodium Leucotomos--An Overview of Basic Investigative Findings", "The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study", https://en.wikipedia.org/w/index.php?title=Phlebodium_aureum&oldid=1156370633, Flora of Saint Vincent and the Grenadines, Flora of the United States Virgin Islands, Articles lacking in-text citations from February 2020, Taxonbars with automatically added basionyms, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 22 May 2023, at 14:24. Rain or shine, January through December, I dont care what time of year it is, I want people to wear sunblock.. Poster at Practical Dermatol Dermatopath Symposium; Aug. 14, 2014; Vail, Co. J Drugs Dermatol. A randomized, double-blind study was designed to determine whether the use of P. leucotomos extract could reduce the use of topical corticosteroids in children and adolescents with atopic dermatitis2. What you eat affects many aspects of health including your skin. Int J Mol Sci. Thus, this natural plant extract has the potential to complement sunscreens and other methods of photoprotection. Still, more studies are needed. View abstract. Because there was no change in the levels of antioxidant enzymes on Western blots, this beneficial effect is likely due to the direct antioxidant properties of P. leucotomos. Members of the non-grammatids in this subfamily include the genera Phlebodium as well as Polypodium, from which Phlebodium is derived and which most likely is its closest relative. View abstract. How Polypodium Leucotomos Protects Your Skin from Sun Damage While current research is promising, more extensive studies are needed. A study published in 2016, discusses the role of polypodium leucotomos for cancer prevention among other health benefits. Careers, Unable to load your collection due to an error. J Drugs Dermatol. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Therefore, you should consult your healthcare professional before taking fernblock to avoid any unwanted side effects. Nevertheless, a study published in the Journal of Clinical and Aesthetic Dermatology in 2015, investigated the safety and effectiveness of taking 240 mg of polypodium leucotomos for 60 days in healthy adults. I want to help other fitness enthusiasts in their journey to a healthier lifestyle and avoid wasting their time on ineffective supplements the same way I did in the past. HHS Vulnerability Disclosure, Help They contain antioxidants and other compounds that may protect against skin damage caused by inflammation and unstable molecules called free radicals (2, 3). Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat model. Subjects in the PLE group had a 22-fold greater incidence (odds ratio) of an increase in UVB MED compared to the Placebo group after 28 days of treatment (p=0.01)32. Methods Find.Exp Clin Pharmacol 2000;22(7):585-594. Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption. 2005 - 2023 WebMD LLC, an Internet Brands company. Jaczyk A, Garcia-Lopez MA, Fernandez-Peas P, et al. 2012;103(7):599-607. In order to get the SPF they advertise on the bottle, it really needs to be applied in a nice, healthy amount and then it needs to be reapplied throughout the day, she said. A review study published in 2018, mentions polypodium leucotomos as one of the therapies that can be included in preventing and treating rosacea. Exposures were then repeated after oral administration of two doses of P. leucotomos capsules (7.5 mg/kg each). Polypodium leucotomos is effective for acne as a result of its anti-inflammatory properties, which help in and boosting skin health by preventing cellular damage associated with UV exposure, sun damage, inflammatory conditions, and oxidative stress while also stimulating the production of new skin proteins through its antioxidant activity. Of the 30 subjects, P. leucotomos completely blocked PLE lesion development in 9 following UVA photoprovocation (i.e. Dr. Elmets is a consultant for Ferndale Healthcare, Inc. National Library of Medicine Several studies have shown that antioxidants in Polypodium leucotomos specifically protect skin cells from free radical damage associated with UV exposure (1, 5, 6, 7). In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions. ABSTRACT: Polypodium leucotomos is widely available as an oral supplement and has been shown to exhibit photoprotective properties which might provide adjunctive benefit when used along with topically applied suncreens. Similarly, another recent study in the Journal of Frontiers in Medicine in 2021, reiterates Fernblocks function in improving sunscreen protection. How is polypodium leucotomas given? J Drugs Dermatol. All rights reserved. Be sure to follow relevant directions on product labels and consult your, The Role Gut Bacteria Plays on the Overall Body, Eczema (atopic dermatitis). 3 However, compliance with frequent sunscreen application is difficult; a more . Other beneficial effects of feeding P. leucotomos included a significant decrease in UV-induced inflammation including a 60% decrease in neutrophil infiltration into the skin at 24 hours and a 50% decrease macrophages in the skin at 24 and 48 hours11. Koch H, Wittern KP, Bergemann J. Investigators sought to determine the effect of P. leucotomos on the immune system. Possible Side Effects and Recommended Dosage, 6 Sun-Protection Foods to Turn Your Skin Into an Anti-Wrinkle Fortress, Heres How Much Damage a Really Bad Sunburn Can Do, Anti-Inflammatory Diet 101: How to Reduce Inflammation Naturally. . Keep in mind that natural products are not always necessarily safe and dosages can be important. Actas Dermosifiliogr. Polypodium leucotomos has been proven to be effective in treating melasma owing to its antioxidant, immunomodulatory, and photoprotective properties. An official website of the United States government. Bernd A, Ramirez-Bosca A, Huber H, et al. A study in 40 healthy adults who took a placebo or 240 mg of oral Polypodium leucotomos twice a day for 60 days found that only 4 participants in the treatment group reported occasional fatigue, headaches, and bloating. 2012;89(4):183-4. View abstract. Polypodium leucotomos is a tropical fern that is native to Central and South America. The https:// ensures that you are connecting to the Polypodium leucotomos decreases UV-induced epidermal cell proliferation and enhances p53 expression and plasma antioxidant capacity in hairless mice. Cis-urocanic acid is a well-studied mediator of UVB-induced immune suppression.23 OTHER NAME(S): Anapsos, Calaguala, Difur, Fern, Fougère, P. Polypodium leucotomos is a fern from Central and South America. Walterscheid JP, Ullrich SE, Nghiem DX. Other effects observed were suppression of solar simulated radiation induced transcriptional activation of nuclear factor-kappaB (NFB) and activator protein-1 (AP-1), both of which have been implicated in UVB-induced skin carcinogenesis. Fernblock is a standardized natural extract of Polypodium Leucotomos, a plant found in tropical areas like Central and South America. Polypodium leucotomos is a tropical fern native to the Americas. 2007 Aug;21(7):942-50. doi: 10.1111/j.1468-3083.2006.02132.x. 3 Locally known as "calaguala" in reference to the species and "anapsos" when referring to the extracts, 1 PL was traditionally used for . Mutations in cancer genes of UV-induced skin tumors of hairless mice. In a study designed to assess the effects of P. leucotomos on the common deletion in human subjects exposed to UVA30, ten healthy adult volunteers were then exposed to doses of UVA radiation ranging from 1035 J/m2 from an artificial UVA light source. A review study published in the International Journal of Molecular Sciences in 2011, describes its positive impact on treating skin conditions like sunburn, eczema, and psoriasis and preventing aging. Polypodium leucotomos is a fern from Central America. Nevertheless, more research is needed to fully understand the possible side effects (9, 14). Fibroblasts obtained from healthy volunteers were treated with an extract of P. leucotomos and then exposed to UV-A and UV-B radiation21. Other members include Pecluma, Pleopeltis, Microgramma, and Pleurosoriopsis. Del, PGJ, De, SGF, and Colomo, GC. This fern is rarely terrestrial in habitat, usually colonizing the canopies of tropical rainforests and the dwarf palms of subtropical forests. A study published in the Journal of the European Academy of Dermatology and Venereology in 2007, concluded that theres a positive impact on re-pigmenting of vitiligo in light skin types after using NB-UVB phototherapy is combined with oral polypodium leucotomos. According to one study from The Journal of Clinical and Aesthetic Dermatology, Polypodium leucotomos, when taken orally for a regular period of time, proved to be an effective means for reducing the damaging effects of ultraviolet radiation.. Why is Polypodium leucotomos good for Anti-aging? official website and that any information you provide is encrypted Metabolic effects of calagualine, an antitumoral saponine of Polypodium leucotomos. There are no clinical studies on children, pregnant, or breastfeeding women. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. PMID: 29879248. They also had a reinforced network of dermal elastic fibers14. View abstract. 2015;41(8):898-902. One study demonstrated that pretreatment of human keratinocytes with P. leucotomos inhibited solar-simulator-UV-mediated increase of tumor necrosis factor-alpha and nitric oxide production and prevented nitric oxide synthase induction20. J Eur Acad Dermatol Venereol 2007;21(7):942-950. In an in vitro model using human leukocytes P. decumanum was had the ability to inhibit the formation of the inflammatory mediator leukotriene B4, which is present in abnormally high quantities in psoriatic skin27.